Isolation and Screening of Fibrinolytic Enzymes producing Bacterium Strain from Soil Waste

Fibrinolytic protease is well known as a sub class of protease, it has an ability to degrade fibrin (Fujita et al., 1993, 1995; Jeong et al., 2001, 2004; Leonardi et al., 2002; Sumi et al., 1995; Wong et al., 2004). Fibrin is normally formed from Fibrinogen by the action of Thrombin (EC 3.4.21.5). It is sliced by plasmin (EC 3.4.21.7) which is activated from plasminogen by tissue plasminogen activator (Voet et al., 1990). In balanced condition, fibrin clots are hydrolysed by plasmin to avoid thrombosis in blood vessels. However, in unbalanced condition, as a result of pathophysiological disorders, the clots are not hydrolysed. Deposition of fibrin in blood vessels normally increases thrombosis and other cardiovascular diseases such as high blood pressure, acute myocardial infarction, ischemic heart disease, valvular heart disease, peripheral vascular disease, arrhythmias, stroke etc. (Bode et al., 1996; Yoshinori et al., 2005).